Depression & Anxiety

Mood & Depression

Supplements and protocols ranked by XP

50XP

Reduces symptoms of depression, with moderate effects in trials that mostly tested aerobic exercise.

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36XP

Mindfulness programs modestly reduce depression symptoms, with an effect a little smaller than for anxiety.

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30XP

EPA-rich fish oil (about 1 g a day) eases depressive symptoms a little; DHA-only products do not.

Studies123
28XP

Bright light lowers depression symptoms in trials, though most tested light boxes rather than morning sunlight.

Studies12
26XP

Lifting weights reduces symptoms of depression in trials, though the studies are small and the best-designed ones show smaller effects.

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23XP

Small improvement in low mood in healthy adults across 20 trials; effects vary by strain.

Studies12
23XP

Breathing practices reduced depressive symptoms by a small-to-moderate amount across 18 randomised trials, mostly in people without a diagnosis.

Studies1
22XP

Eases depressive symptoms, mainly as an add-on to standard care, based on small trials.

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21XP

May ease mild to moderate depression, mostly from small trials.

Studies123
21XP

Eases self-rated depression symptoms in small trials, mostly from Iran, but clinician-rated scores did not improve and the newest independent trial found no effect.

Studies123456
20XP

In a 12-week trial of 67 adults with depression, a Mediterranean-style diet programme with dietitian support helped more people reach remission than social support alone (32% vs 8%).

Studies123
13XP

Adults taking 7,000 or more steps a day had about a 31% lower risk of developing depression than those taking fewer, in studies that followed people over time.

Studies1
13XP

May ease depressive symptoms a little, mostly in people who are deficient; large trials in healthy adults were null.

Studies1234
12XP

May ease low mood in stressed adults, but trials are small and mostly not in clinical depression.

Studies1
11XP

The pooled effect of expressive writing on depression, anxiety and stress was very small, and trials in people with cancer found no effect on depression.

Studies12
9XP

Irregular bed and wake times go with more depression and anxiety symptoms in studies, but this shows a link, not cause.

Studies1